3 members and 96 guests

Wow! Where is everyone and why aren't our guests members? Please join. It's a great community. OK I said my peace. I thought I would be so...

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The reasons we eat (and overeat)

Studies highlight potential reasons people overeat to the point of weight gain.

From the RSS feed of CalorieLab News (REF3076322B7)

The reasons we eat (and overeat)

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Thermogenic Burning

Any one heard of "thermogenic burning" ?

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MS Related: Biogen Updates Tysabri Label To
Reflect Risk With Longer Use

November 6, 2009

By Thomas Gryta, Of DOW JONES NEWSWIRES

NEW YORK -(Dow Jones)- Biogen Idec Inc. (BIIB) amended the U.S. label of multiple sclerosis treatment Tysabri, sold with Elan Corp. PLC (ELN), on Friday to reflect that the risk of a rare brain infection rises with longer usage.

The changes, which were expected, note that the occurrence of progressive multifocal leukoencephalopathy, or PML, in patients treated for 24 to 36 months is "generally similar" to the 1-in-1,000 rate seen in clinical trials. The changes warn that there is limited experience with the drug beyond three years of treatment.

Lazard Capital Markets' analyst Joel Sendek said the changes appeared to be benign.

"We do not expect physicians to significantly change their Tysabri prescribing habits in the near-term," Sendek said in a research note. He continues to project 2010 Tysabri sales of $1.1 billion.

Biogen had previous said it was discussing a label change with the Food and Drug Administration to include duration-related risk, but some on Wall Street had feared it would include suggestion for duration limits, or taking a " holiday" from treatment.

Barclays Capital analyst Jim Birchenough wrote Friday that he believes the new label will ultimately slow sales growth of the drug.

Aside from duration information, the updated label includes details on using plasma-exchange therapy, which removes large molecules from the body's blood circulation, thereby accelerating removal of Tysabri and theoretically improving the immune response to PML infection.

It also explains that inflammation of the rebuilding of the immune system can occur following discontinuation of Tysabri in patients with PML.

Continue reading this article at Nasdaq.com

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Gees video blog...

I Just started this week. http://www.geesjourney.com (http://www.geesjourney.com/). Hoping to keep myself motivated through these videos. Leave me...

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Another likely cause of obesity: Stress

People under stress are more likely to eat junk food, and even kids aren't immune to feeling stressed out these days. Plus, the top junk foods for stress eating.

From the RSS feed of CalorieLab News (REF3076322B7)

Another likely cause of obesity: Stress

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Hello

Hi, I've just joined the forum and am beginning my weight loss program/positive life style change for life! I am determined to make it! I've...

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When Lack of Sleep Can Be Deadly...

At the University of Pennsylvania School of Medicine, David Dinge is studying how lack of sleep affects ones activities. He is studying how lack of sleep over time affects the brain and to find out how much sleep is really necessary to get back on track. In particular, some people are more affected than others when it comes to chronic sleep deprivation.

In Dinges study, volunteers are limited to 4 hours of sleep a night for 5 nights, and then allowed to sleep for up to 10 hours for 2 days.

In her article entitled ?Dying to Sleep? published in Science News in October 2009 author Tina Hesman Saey discusses Dinges study.



A volunteer named Heather is behind the wheel in a driving simulator. She has electrodes taped to her head. In this study Heather has gotten only 4 hours of sleep every night for the last 4 nights. She is in a car simulator driving on make believe roads and highways, sharing the road with truckers, bright lights and zig zagging roads. She states ? My limbs feel heavy?. Saey reports that the electrodes on Healthers head are monitoring her brain waves and eye movements so that researches can detect even brief bouts of sleep. Heather has reported feeling light headed and dizzy- and yet she has?nt nodded off and tests show that her driving has not affected by lack of sleep.

Saey reports that the tests in Dinges lab have shown how severly most people?s performance of daily activities can deteriorate with sleep loss. Heather may be one of the few people whose brain is not adversely affected with chronic sleep loss. By looking at Heathers genes, researches can then develop drugs that affect those genes and help ordinary people resist making mistakes after chronic sleep deprivation.

Another volunteer, James who is an architecture student, studys all night especially at the end of the term. He is referred to as a "short sleeper". He functions normally on short amounts of sleep. When tested after sleep deprivation he smashes his vehicle into the back of a truck.

Dinges says that many short sleepers are convinced that they function well on less sleep. He has noticed in his study that most people do not predict how well they will perform after sleep deprivation. Dinges has also found that ?some people fall apart after missing just a few hours of sleep?. Other shows a slow steady decline in their ability to remain awake and clear. Other people like Heather, is categorizes as ?type 1s?- these people?s performance does not change with 5 days of restricted sleep. According to Dinges, ?people are walking around with grossly different brain activity profiles?.

So whats the magic number of how many hours of sleep one should get every night? According to the author, Saey, her research has shown that the ?normal? range includes 6 to 10 hours of sleep per night, depending on the person. In her research she further highlights that ?sleeping about 7-8 hours carries the least risk of obesity, diabetes, heart disease and other illnesses?.

The National Sleep Foundation conducts research on people?s sleep habits. Their research shows that overall, people are just getting less sleep in general. Here some interesting facts they have found:

• In 2009, 20% of those surveyed said they slept less than 6 hours on weeknights, compared with an earlier study in 1998 which was 12%
• In 2009, respondents reported sleeping 7.1 hours on weekends, down from an average of 7.8 hours in 1998>

• The Cost of Not Getting A Good Nights Sleep
• Why Adequate Neck Support While You Sleep Is Vital To Stop Neck Pain
• Which Sleeping Position is Best For You?
• 6 Ways to Get a Better Nights Sleep
• How to Get Better Sleep
• Natural Sleep Secrets- How to Cure Insomnia

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A new and "different' book on obesity

Hello everyone Just read this interesting book that may be of interest, because it is "different." Below are excerpts from book's preface and...

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